HMGB1 and neoplasm: Immunogenic cell death induced by UVB-irradiation stimulated the immune system through the release of damage-associated molecular patterns (DAMPs), including the exposure of calreticulins and release of ATP, HMGB1 and heat shock proteins (gp96, HSP70 and HSP90) (25).Based on their results, we used an irradiated dying allogeneic tumor cell line as a tumor antigen.