Pathway network and gene expression analyses confirmed time-dependent reprogramming of the ischemic and ischemia non-affected LV gene expression in response to the r-I/R stimulus without MI, with activation of the Ca-signaling, adipocytokine and insulin signaling pathway in the ischemic region early after I/R, and the immunomodulatory pathways at the time of the induced cardioprotection, during the late window of protection. The gene discussed is INS; the disease is ischemia.