Since secretion of Eotaxin, MCP1, KC/IL-8, and Rantes by the eAT also increases upon prolonged exposure to HFD33, 34, our findings suggest the involvement of Ankrd26 down-regulation in raising and/or sustaining the low-grade inflammatory response which occursin the eAT after long-termHFD feeding and is implicated in the development of insulin resistance and T2D33, 34, 35. Here, CCL5 is linked to Insulin resistance.