ANKRD26 and obesity due to melanocortin 4 receptor deficiency: The relevance of these observations to humans is supported by our further findings in obese individuals with normal glucose tolerance, revealing that the reduction of ANKRD26 expression in VAT negatively correlates with the serum concentrations of inflammatory markers and pro-inflammatory chemokines, which are associated to obesity in humans38, 39 and whose increased levels predict occurrence of T2D38, 39, 40, 41, 42, 43.