Interestingly, we reported that CCN1 was up-regulated in psoriatic skin lesions and promoted keratinocyte (KC) proliferation and activation via the α6β1/PI3K/Akt/NF-κB pathway in psoriasis, indicating that CCN1 was involved in the development and pathogenesis of psoriasis27, 30. The gene discussed is CCN1; the disease is psoriasis.