SHBG and Hepatic steatosis: In addition, sex hormone binding globulin (SHBG), a glycoprotein that is produced primarily by hepatocytes and serves to transport sex steroid hormones through the blood to target tissues, was first associated with hepatic steatosis through studies of monosaccharide-induced hepatic lipogenesis in animals, a treatment that suppressed expression of sex hormone–binding globulin62.