It has been reported that FAK-expressing AML regulates IL-6, IL-8, CXCL-12 and Dkk1 expression in MSCs thereby hijacking the leukemic niche25 and an earlier study indicated that cordycepin downregulates integrin/FAK expression and cell migration via impairing NFκB signaling in hepatocellular carcinoma51. This evidence concerns the gene PTK2 and acute myeloid leukemia.