In summary, our studies revealed RPGRIP1L as a novel MyoVa-binding protein – the first to be demonstrated to interact with MyoVa at the centrosome – and uncover an unprecedented link between MyoVa and ciliogenesis, providing new perspectives for studies aiming to better understand why defects in MyoVa cause neurological disorders in Griscelli syndrome patients. The gene discussed is RPGRIP1L; the disease is Griscelli syndrome.