CDK4 and lung carcinoma: Likewise, miR-200 has been identified as a powerful marker of the epithelial phenotype of cancer cells72, while miR141–200c targets β-catenin, the downstream effector of the Wnt proliferation pathway73, and miR-545 targets complex-forming CCND1 and CDK4 with potentially suppressive effects on the proliferation of lung cancer cells58.