CD8A and neoplasm: Tumors undergo a CD8+ T-cell mediated selection process and a down-regulation of MHC I expression in advanced stages23 – in EOC we see two parallel and mutually exclusive ways of immune escape: we hypothesize that EOC tumor cells are either (i) activating the immune regulatory mechanism of PD-L1 expression to inhibit T cell receptor signaling or (ii) down-regulate MHC I molecules as seen in PD-L1 negative tumor tissues so that the immune system lacks an initiating signal (tumor-associated antigens).