Seminal studies have demonstrated features of senile plaque accumulation and neurofibrillary tangle formation are essential to the neuropathological diagnosis of Alzheimer’s disease (AD) (Tomlinson et al. 1970) and more specifically emphasizing the importance of dystrophic neurites positive for hyperphosphorylated tau in neuritic plaques in AD cases compared to controls (Dickson et al. 1988; Probst et al. 1989; Arai et al. 1990). Here, MAPT is linked to Alzheimer disease.