In cases fulfilling neuropathological criteria for mixed dementia [AD and limbic/neocortical (LBD)] with different clinical phenotypes (i.e., AD or DLB), we found differences in the pathological burden and topographical distribution of hyperphosphorylated tau (HP-T), β amyloid and α-synuclein (α-syn) loads between clinical AD and DLB which were not detected using semi-quantitative criteria (Walker et al. 2015). This evidence concerns the gene MAPT and Lewy body dementia.