Similar to BRAF, melanoma driver genes like ras-related C3 botulinum toxin substrate 1 (RAC1, rho family, small GTP binding protein Rac1, Gene ID: 5879), serine/threonine kinase 11 (STK11, LKB1, Gene ID: 6794), or NRAS have such a distorted distribution of nucleotide transitions, since activation nucleotide transversions can favor or disfavor the UV melanoma signature. Here, RAC1 is linked to melanoma.