TGFB1 and hepatocellular carcinoma: While the expression of this lncRNA is low in normal hepatocytes, its selective enrichment within EVs correlated with the TGFβ-dependent HCC cells chemoresistance, whereas knockdown of the same lncRNA enhanced the chemosensitivity [56]; (iii) the lncRNA TUC339 was found significantly expressed in EVs derived from HCC cells and was implicated in tumor growth, cell adhesion, and cell cycle progression [57, 58].