Electroporation was used to introduce siRNAs in human peripheral blood exosomes to cause gene silencing of mitogen-activated protein kinase 1 [85] as well as siRNAs against Alpha-synuclein (α-Syn, which aggregates are characteristic pathological feature of the Parkinson's disease (PD) brain) [86]. The gene discussed is MAP2K1; the disease is Parkinson disease.