By demonstrating that GBM-relevant alterations in the EGFR pathway distinctly change the secreted profile of invasion-promoting proteins as well as the expression and phosphorylation status of intracellular proteins, Sangar et al. investigated the effects of EGFR signaling on the secreted levels of proteins implicated in aggressive invasiveness and proliferation of GBM cells (123). This evidence concerns the gene EGFR and glioblastoma.