MCP-1, an inflammatory chemokine involved in the recruitment of monocyte-derived cells such as microglia, is up-regulated in ALS mice (Kawaguchi-Niida et al., 2013) and patients (Henkel et al., 2004; Nagata et al., 2007; Wilms et al., 2003). This evidence concerns the gene CCL2 and amyotrophic lateral sclerosis.