P2RX7 and amyotrophic lateral sclerosis: Despite this, in the current study, BBG had no effect on body weight loss or survival in male SOD1G93A mice, or on ALS score, motor coordination, motor neuron loss, microgliosis, lumbar SOD1 or P2X7, serum MCP-1, splenic leukocyte immunophenotype or P2X7 expression at end-stage in either gender.