Given that a number of changes in the pro-inflammatory and regulatory levels of cytokines and hormones are reported in obesity, as increased levels of TNF-α, IL-6 and leptin as well as reduction of IL-10 and adiponectin, we investigated whether such changes would be found in fat animal model proposed in this study (Fig. 5). The gene discussed is IL10; the disease is obesity due to melanocortin 4 receptor deficiency.