In addition, human studies have shown CD36 to be associated with impaired insulin sensitivity (64–66) and pathogenesis of metabolic disorders such as insulin resistance, obesity, and non-alcoholic hepatic steatosis, and an absence of CD36-mediated lipid uptake in muscle or liver is capable of preventing diet-induced lipotoxicity (67–69). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.