PspA, PspC, Phts, NanA, PLY, RrgA, LytA, and GAPDH have all been demonstrated to induce protection against systemic infection [reviewed in (Darrieux et al., 2015) and (Miyaji et al., 2013)]; PspC, Phts, NanA, and PspA were also protective against nasopharyngeal colonization (Arulanandam et al., 2001; Balachandran et al., 2002; Tong et al., 2005; Hernani Mde et al., 2011), while NanA protects chinchillas against otitis media (Long et al., 2004). Here, SFTPC is linked to otitis media.