In contrast to the high frequency of hemizygous deletions, we found a low frequency of point mutations in RPGs, although we noted recurrent mutations in RPL5, RPL10, and RPL22 in several tumor types as reported previously (Nagarajan et al, 2012; Rao et al, 2012; De Keersmaecker et al, 2013; Novetsky et al, 2013; Table EV2). This evidence concerns the gene RPL5 and neoplasm.