Throughout, RPGs were hit by regional deletions covering multiple genes, and all frequently deleted RPGs were co‐deleted with well‐known tumor suppressor genes, including RPL26 on chromosome 17p, which is always co‐deleted with TP53, and RPS6 on chromosome 9p, which is always co‐deleted with CDKN2A. In addition to copy number changes, we examined the spectrum of point mutations in RPGs using whole‐exome sequencing data from 4,655 TCGA samples. Here, RPS6 is linked to neoplasm.