RPL5 and myelodysplastic syndrome associated with isolated del(5q): In DBA and the 5q‐ syndrome, however, the RPG haploinsufficiency is thought to perturb the stoichiometry of ribosomal proteins, leading to inefficient ribosome assembly and increased concentrations of free ribosomal proteins, some of which (RPL5 and RPL11) regulate key components of the 5S ribonucleoprotein particle (Macias et al, 2010; Donati et al, 2013; Sloan et al, 2013; Goudarzi & Lindstrom, 2016).