Acquired somatic mutations in specific RPGs associate with certain malignancies, including the 5q‐ subtype of myelodysplastic syndrome (hemizygous deletions of RPS14; Ebert et al, 2008), T‐cell acute lymphoblastic leukemia (mutations in RPL5, RPL10, and RPL22; Rao et al, 2012; De Keersmaecker et al, 2013), and microsatellite‐unstable endometrial and gastric cancer (mutations in RPL22; Nagarajan et al, 2012; Novetsky et al, 2013). Here, RPL22 is linked to gastric cancer.