Taken together, this work demonstrates that different pro‐cachectic inducers (i.e. IL‐6 and IFNγ/TNFα) activate STAT3 signaling independently and that this signaling can collaborate with the NF‐κB pathway to induce cachexia through activation of target genes, like iNOS (Fig 7E). Here, STAT3 is linked to Cachexia.