Both these conditions may be related with an increased risk of non-AIDS-defining events in HIV positive subjects: thrombocytosis is a well-known risk factor for vascular ischemic events, whereas thrombocytopenia has been related to high plasma levels of inflammation biomarkers such as IL-6 [31, 32], and to the risk of developing both AIDS and non-AIDS-defining events, including cancer and cardiovascular diseases [33, 34]. This evidence concerns the gene IL6 and cardiovascular disorder.