Bastard et al. [39] have described an inflammation and immune activation status, measured with IL-6, CPR, B-2 microglobuline, D-dimer, sCD14, independently of HIV-related factors (current CD4 or CD8 values, CD4 nadir, CD4/CD8, previous AIDS event, duration or type of ART) in treated, virologically-controlled HIV-infected patients. The gene discussed is CD4; the disease is AIDS.