In fact, even if it is known that some drugs, such as insulin sensitizer metformin [50–52], PPAR-gamma agonists thiazoledinediones [53] calcium channel blockers [54], ACE inhibitors and ARBs [55] may have a positive effect on eNOS expression, no differences were found in the use of these drugs between NAFL and NASH patients in our population. The gene discussed is ACE; the disease is metabolic dysfunction-associated steatohepatitis.