Two subsequent multicenter trials of selumetinib plus docetaxel for patients with advanced NSCLC included mandatory administration of ppG-CSF in the protocol: SELECT-1, evaluating the combination as second-line treatment in KRAS-mutant advanced NSCLC (ClinicalTrials.gov identifier: NCT01933932); and SELECT-2, evaluating the hypothesis that clinical activity of the combination is not limited to patients with advanced NSCLC that harbours KRAS mutations (ClinicalTrials.gov identifier: NCT01750281). The gene discussed is KRAS; the disease is non-small cell lung carcinoma.