The potential benefit of combining MEK inhibitors with chemotherapy has been demonstrated in preclinical studies of tumor xenograft models, in which selumetinib in combination with cytotoxic agents, such as docetaxel or the dacarbazine derivative temozolomide, showed enhanced tumor growth inhibition compared with selumetinib monotherapy, or chemotherapy alone [1, 11]. Here, MAP2K7 is linked to neoplasm.