In SHR and stroke-prone SHR (SHRSP), cerebral arteries (large supply arteries) and arterioles (small, resistance arteries) undergo hypertrophic remodeling [81,82,83] but become less stiff and more compliant due to changes in vessel wall composition (an increased ratio of (compliant) elastin to (stiff) collagen) [81,84]. This evidence concerns the gene ELN and Stroke.