Similar to ETS1, ERG belongs to the class I ETS family (ERG, ETS1 and 2, ETS variant: ETV1–5, ELK1, ELK3, ELK4, ETS2 repressor factor: ERF, FEV, Fli-1 proto-oncogene: FLI1 and GA binding protein transcription factor alpha subunit: GABPα) and possesses oncogenic properties, which activate the phosphoinositide 3-kinase (PI3K) pathway to promote prostate cancer progression [88,89]. This evidence concerns the gene FLI1 and Familial prostate cancer.