INS and type 2 diabetes mellitus: Based on the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway map and affected miRNAs from each sample type, we constructed miRNA-mRNA interaction networks for three key T2DM-associated pathways, T2DM signaling, insulin signaling and adipocytokine pathways in pancreatic islet (Figure 2) and adipose tissues (Figure 3), to better illustrate the complex interactions between mRNAs and affected miRNAs in key tissues associated with the manifestation of T2DM.