In addition to miR-375, other dysregulated miRNAs in the islets (such as miR-7-5p, -369-5p, -129-3p,-136-5p, -187-3p, -589-5p, -224-5p, -655-3p, -495-3p) affect the expression of IRS1, IRS2, AKT1, PPARA, MAPK9, MAPK10, STAT3, PPKAG2, ACSL3 and ACSL4, which are important genes involved in insulin signaling and type 2 diabetes pathways [89,90] (Figure 2A–C), and have been implicated in various events associated with islet β cell development and glucose-stimulated insulin secretion (GSIS) [23,36,90,91]. Here, IRS1 is linked to type 2 diabetes mellitus.