Dysfunction of adipose tissues may induce inflammation and insulin resistance by releasing pro-inflammatory cytokines, such as TNFA (tumor necrosis factor alpha) and IL-6 (interleukin 6), as well as energy regulating hormones including LEP (leptin), ADIPOQ (adiponectin), RETN (resistin) and ITLN1 (intelectin 1) [96]. The gene discussed is LEP; the disease is Insulin resistance.