VEGFA and Stroke: Another miRNA, miR-107, was also shown to be upregulated in the ischemic boundary zone on day 3 and day 7 after permanent middle cerebral artery occlusion in the rat and to contribute to post-stroke angiogenesis by targeting Dicer-1, an enzyme which regulates processing of miRNA precursors and regulates of VEGF in endothelial cells [54].