Based on the prediction of the transcription factor website and our experimental results, we found that E2F1 directly binds to the ITGA1 promoter and that the expression of ITGA1 positively correlated to the expression of E2F1 in HCC cells and tissue, suggesting that E2F1, the powerful transcription factor, also transcriptionally upregulates ITGA1 expression in HCC. Here, E2F1 is linked to hepatocellular carcinoma.