So, we screened potential metastasis-related differential expression genes from the cDNA microarrays of Huh7 and SMMC-7721 cells between the control and d-ICD treatment groups [7], and due to our knowledge of its gene biological function, we selected the target gene ITGA1. Next, we cultured HCC cells with d-ICD and confirmed the decreased expression of ITGA1 at the mRNA and protein levels. Here, ITGA1 is linked to hepatocellular carcinoma.