Thus, in the present study, we used MM-MVs to treat human proximal tubular (human kidney-2, HK-2) cells to observe their changes in proliferation, apoptosis, and epithelial-mesenchymal transition (EMT) in vitro, and clinically investigated the associations between peripheral circulating CD138+ cirMV counts and severity of RI in patients with MM. The gene discussed is SDC1; the disease is Miyoshi myopathy.