Thus, in the present study, we used MCAO and NMDA-induced excitotoxicity models of ischemic stroke to further investigate the neuroprotective effects of PF as well as the underlying mechanism, by focusing on the Ca2+/CaMKII/CREB signaling pathway, that was closely related to anti-apoptotic signaling. The gene discussed is CAMK2G; the disease is ischemic stroke.