It is very likely that due to the low cytotoxic activity of CD8+ T lymphocytes and the absence of natural killer (NK) cells, in “phase II” the host is trying to isolate tumor cells from the rest of the body, while tumor cells are actively creating an immunosuppressive microenvironment by inducing stromal reorganization and generation of a structure similar to a TH2 granuloma [30]. This evidence concerns the gene CD8A and neoplasm.