IFNG and neoplasm: We have previously reported that a mouse fibrosarcoma tumor clone (which is MHC-I negative in baseline conditions, but inducible by IFN-gamma), produces “MHC-I positive” spontaneous lung metastasis in immunodeficient nude/nude mice lacking T-cell, while in syngeneic immunocompetent mice it generates “MHC-I negative” metastases [22].