We noticed that, in HCC samples, Runx2 expression is related to Galectin-3 expression (χ2 = 5.92, p = 0.018); furthermore, we examined the Galectin-3 expression level in HepG2 and SMMC7721 cells Runx2 transfected models. Here, RUNX2 is linked to hepatocellular carcinoma.