Cell cycle pathways are often regarded as central to the cascade of RGC death in POAG.[60] Our GWAS hits of TMCO1 and CDKN2B-AS1 in glaucoma are both genes related to the cell cycle.[10] Additionally, functional experimental studies have demonstrated that cell cycle genes are the most up-regulated genes in animal models of ONH damage via elevated IOP and ON crush injury.[60] These findings suggest that cell cycle pathways are involved in both HTG and NTG as supported by the outcomes of our network analysis. The gene discussed is TMCO1; the disease is glaucoma.