While it is well known that cataracts can contribute to the pathogenesis of angle-closure glaucoma, pathway analyses with GWAS SNPs[35] have identified associated SNPs in genes CDK4PS, NFYAP1, and LGMNP1 shared between the POAG and cataract phenotypes, suggesting a potential genetic connection between these conditions. The gene discussed is NFYAP1; the disease is angle-closure glaucoma.