Cell cycle pathways are often regarded as central to the cascade of RGC death in POAG.[60] Our GWAS hits of TMCO1 and CDKN2B-AS1 in glaucoma are both genes related to the cell cycle.[10] Additionally, functional experimental studies have demonstrated that cell cycle genes are the most up-regulated genes in animal models of ONH damage via elevated IOP and ON crush injury.[60] These findings suggest that cell cycle pathways are involved in both HTG and NTG as supported by the outcomes of our network analysis. This evidence concerns the gene TMCO1 and open-angle glaucoma.