RINT1 and cancer: Although these in vivo studies suggested that heterozygosity for a knockout of Rint1 did not enhance intestinal tumorigenesis in ApcMin/+ mice, in vitro studies indicated that missense mutations in Rint1 do have the potential to impact protein-protein interactions involving Rint1. We also found that over-expression of RINT1 and somatic missense mutations in RINT1 were relatively frequent in human colorectal cancers whereas loss of RINT1 or RINT1 expression were infrequent events in these cancers.