GATA3, a zinc-finger transcription factor belonging to the GATA family,1, 2 is first identified to be critical in T-cell differentiation.2, 3 Later on, it is discovered to have pivotal roles in development of various human organs.4, 5, 6, 7, 8, 9 The association of GATA3 with human malignancies has been reported in breast cancers, neuroblastomas, endometrial carcinomas, urothelial carcinomas and soft tissue sarcomas.10, 11, 12, 13, 14 However, its function remains elusive. Here, GATA3 is linked to endometrial carcinoma.