MMP12 and myelodysplastic syndrome: We performed mRNA expression profiling of MMP families (MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP11 and MMP12) in MSCs, and found that MMP1 was decreased in MDS-derived MSCs compared with normal MSCs (Supplementary Fig. S1 and Fig. 2a).