Although these findings await further validation using additional experimental approaches, the effects of EPHB6 modulation on the metastatic potential of colon cancer cells are consistent with the role of this EPH receptor in the metastatic progression of other tumor types, such as melanoma, breast and lung tumors11, 13, 25, 26, 27, 33. The gene discussed is EPHB6; the disease is malignant colon neoplasm.