EPHB6 and intestinal neoplasm: Using the genetic model of intestinal tumor initiation we found no differences in the weight of Apcmin/+ mice that were EphB6+/+, EphB6+/− or EphB6−/− at the age of 20, 60 or 130 days (two-way analysis of variance –ANOVA, p = 0.68; Fig. 4A).