However, consistent with the findings of the mouse model using genetic tumor initiation, no differences were observed in the number (Student’s t-test p > 0.49; Fig. 4E) or size (Student’s t-test p > 0.61; Fig. 4F) of the tumors in EphB6 wild type and knockout mice after AOM treatment. The gene discussed is EPHB6; the disease is infectious otitis media.