Using a more direct approach, we showed that Gal-3 depletion in our pancreatic cancer cell model is accompanied by a strong decrease of MUC1 and MUC4 transcript level(s) but with no significant change of MUC16. In addition in the human tissue levels, we highlighted a significant correlation only between LGALS3 and MUC4 mRNA levels suggesting that if a link exists between Gal-3 and mucin mRNA levels in cancer cells, it certainly concerns MUC4 first. This evidence concerns the gene MUC4 and familial pancreatic carcinoma.