SAHA, another HDAC inhibitor, induces apoptosis of CTCL cells by accumulating histone acetylation, increasing expression of p21CIP1 and bax, decreasing of Stat6 and phospho-Stat6 proteins, activating caspase-3 and cleaving PARP28. This evidence concerns the gene CDKN1A and primary cutaneous T-cell non-Hodgkin lymphoma.