However, these Pin1 null mice are highly resistant to Ras, Neu/HER2 or mutant p53-induced breast cancer15, 16, Myc-induced Burkitt’s lymphoma17 or Notch3-induced T-cell acute lymphoblastic leukemia18, demonstrating an essential role for Pin1 in tumorigenesis of many cancer types. This evidence concerns the gene PIN1 and cancer.