In spite of the insignificant differences in clinical M stage and significant differences in clinical N stage (N1/M1, CAB 29.91%/23.08% vs. GnRH 11.59%13.04%, p = 0.0022/0.0711) between CAB and GnRH groups, depending on the presence of bone metastasis, a 6.6% decrease in lumbar spine BMD and a 6.5% decrease in femoral neck BMD after 6 months of CAB were observed in patients with bone metastasis14 (Table 1). This evidence concerns the gene GNRH1 and bone metastasis.