GNRH1 and metastatic neoplasm: Another combination regimen of strengthening the efficacy was the combined androgen block (CAB) with GnRH agonist plus bicalutamide, which has significant advantages over castration alone or GnRH agonist monotherapy, such as a higher proportion of patients with complete and partial responses, improved control of pain associated with metastatic disease, longer disease-free survival, and longer overall survival by an average of 3–6 months, as compared with combined treatment with the anti-androgen initiated later4, 5, 6.