ACE and open-angle glaucoma: In terms of preferential reduction of the difference between SBP and DBP, ACE-inhibitors, diuretics, dihydropyridine calcium antagonists and vasopeptidase inhibitors seem to be more effective than beta-blockers51 We performed additional analysis to exclude the effect of BP medication, and multivariate Cox’s regression analysis showed that subjects without BP medication in the fourth quartiles of SBP SD or CV were significantly more likely to develop POAG than subjects without BP medication in the first to third quartiles of SBP SD or CV (S2.