IGF1R and hepatocellular carcinoma: Several targets of miR-139-5p include Rho-Kinase 2 and c-Fos in hepatocellular carcinoma (HCC), type 1 insulin-like growth factor receptor (IGF-1R) in CRC18, 19, 20 and signaling pathways such as TGF-β, Wnt, Rho, and APK/PI3K in breast cancer17 have been known to be deregulated.