The amplicon on murine chr19 is syntenic to the human 9p24.1 region, which is frequently amplified in Hodgkin's Lymphoma (HL) and primary mediastinal B-cell lymphoma (PMBCL) and contains the tumour-promoting genes JAK2 and CD274 (PD-L1)23. The gene discussed is JAK2; the disease is neoplasm.