MYC and neoplasm: To experimentally validate the tumour-suppressor function of Bcor in Eμ-Myc lymphoma we knocked down or deleted Bcor using shRNA or CRISPR-Cas9 methods, respectively, in Eμ-Myc haematopoietic progenitor cells and transplanted them into lethally irradiated syngeneic mice (Fig. 4a).