Overexpression of Bcl2, forced expression of other pro-survival BCL2 family members (for example, Bclxl, Mcl1) or deletion of pro-apoptotic BH3-only genes (for example, Bim, Bmf, Bad) can accelerate lymphoma development in the Eμ-Myc mouse15, 16, 17, 18. The gene discussed is BCL2; the disease is lymphoma.