MYC and lymphoma: We also found that Eμ-Myc lymphomas did not show appreciable activation of JAK2 signalling as assessed by phosphorylation of the downstream target STAT5 and furthermore, JAK2 inhibition using FDA-approved small molecule inhibitor ruxolitinib had no effect on survival of Eμ-Myc lymphomas cultured in vitro (Supplementary Fig. 4).