Deregulation of the AKT-MTOR-eIF4E pathway has been shown to co-operate with MYC in Eμ-Myc lymphomagenesis25 and treatment of Eμ-Myc transgenic mice with mTORC1 inhibition by everolimus during the pre-malignant stage of disease significantly delayed lymphoma onset20. This evidence concerns the gene AKT1 and lymphoma.