2007; Barker & Clevers 2007). Many studies have demonstrated that LGR-5 protein has a close association with initiation and repetition of different cancer types (Aoki et al. 2005; Tanese et al. 2008). LGR-5 protein was over-expressed in colorectal cancer and crypt LGR5 + stem cells in intestine have been observed to be represented as the cell of origin for intestinal cancer (Barker et al. 2009). Here, LGR5 is linked to cancer.