2007; Barker & Clevers 2007). Many studies have demonstrated that LGR-5 protein has a close association with initiation and repetition of different cancer types (Aoki et al. 2005; Tanese et al. 2008). LGR-5 protein was over-expressed in colorectal cancer and crypt LGR5 + stem cells in intestine have been observed to be represented as the cell of origin for intestinal cancer (Barker et al. 2009). This evidence concerns the gene LGR5 and colorectal cancer.