Interestingly using double genotype analysis we found that the frequency of combinations of Apo AI and AIV mutants were significantly higher in patients as opposed to controls, indicating that subjects carrying even one mutant alleles of both these polymorphisms carry at least 1.3-fold higher risk of developing CAD (p = 0.03, OR = 1.33, 95%CI = 1.06–1.65) (supplementary Table 2). The gene discussed is APOA1; the disease is coronary artery disorder.