CFTR and cystic fibrosis: Although these approaches solve the issue of being able to identify uncommon mutations particularly in minority populations,34 it creates a new issue, which is the identification of babies who do not have CF but rather CRMS.35 The Cystic Fibrosis Foundation describes CRMS as infants with hypertryp-sinogenemia on newborn screening who have sweat chloride values <60 mmol/L and up to 2 CFTR mutations, at least 1 of which is not clearly categorized as CF causing.36