NUDT1 and hepatocellular carcinoma: Further, upregulation of MTH1 mRNA was significantly reversed by low or high dose HS-1200 therapy; high dose appeared to have a higher efficacy in this respect (HCC + low dose HS-1200, 9.48 ± 0.46; HCC + high dose HS-1200, 6.13 ± 0.33; P < 0.05 versus HCC).