NUDT1 and chronic hepatitis C virus infection: 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a well-accepted biomarker of ROS-triggered oxidative DNA damage [15] and is also identified as a risk factor for developing HCC in patients with chronic hepatitis C virus infection [16]. mutT homologue gene 1 (MTH1), a hepatocyte DNA repair gene, encodes MTH1 protein which favors the repair of oxidation-induced DNA damage by inhibiting the incorporation of oxidized dNTPs [17, 18].