AGTR1 and brain edema: In addition, because the level of antigen-specific T-cell recruitment to the brain is governed largely by the magnitude of splenic T-cell priming rather than by secondary differences in brain-localized T-cell migratory cues (Lin et al., 2014; Howland et al., 2015a), these data suggest how inhibition of AT1R could increase the resistance of mice against CM, promoting survival, improving cognitive parameters, and reducing cerebral edema (Silva-Filho et al., 2013, 2016; Gallego-Delgado et al., 2016).