Here, we examined the mechanisms of action of AT1R specifically in the Plasmodium-specific CD8+ T-cell response during blood-stage malaria, by using wild-type (WT; AT1R+/+) or AT1R−/− CD8+ T cells from ovalbumin (OVA)-specific TCR transgenic mice (OT-I), which allow the tracking of the antigen-specific CD8+ T cell response (Lundie et al., 2008; Miyakoda et al., 2008; Cockburn et al., 2010; Chen and Zavala, 2013; Silva-Filho et al., 2016). The gene discussed is AGTR1; the disease is malaria.