Although caspase-11 is not required for NLRC4-dependent pyroptosis, nor for the restriction of flagellated Legionella infection (Cerqueira et al., 2015), there is some evidence that Legionella complete their terminal rounds of proliferation within the cytosol (Molmeret et al., 2007) and, thus, may activate caspase-11 upon escaping its vacuole, in order to facilitate egress. Here, NLRC4 is linked to legionellosis.