IGHE and allergic disease: To date, the only data published on the family burden in non-IgE mediated allergies is the study by Klinnert et al. [7] on families with children with Eosinophilic Oesophagitis (EoE), a mixed non-IgE and IgE-mediated condition and Greenhawt et al. on Food Protein Induced Enterocolitis Syndrome (FPIES) [15].